I found the field of Engineering; Materials Science very interesting. Saw the article Pre-blocked molecular shuttle as an in-situ real-time theranostics published in 2019.0. Computed Properties of C4H14Cl2N2S2, Reprint Addresses Jiang, C (corresponding author), Fudan Univ, Sch Pharm, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ,State Key, 826 Zhangheng Rd, Shanghai 201203, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride
Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where a default supramolecular-dye couple was pre-blocked. The rational design, synthesis, characterization and proof-of-concept of this strategy were described in detail. The drug-release upon reducing environment can be translated into near-infrared (NIR) fluorescence signal (OFF-to-ON), allowing to track the drug-release procedure by multi-modal images including IVIS, FLECT and photoacoustic imaging. The versatile nanotheranostics system can target to triple negative breast tumor via conjugated F3 peptide, and show an improved anti-tumor efficacy with much lower side effect. The intelligent nanotheranostics system based on molecular shuttle provides new reference for precision medicine in preclinical trial and postclinical evaluation.
About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Sun, T; Zhang, GP; Wang, QB; Guo, ZY; Chen, QJ; Chen, XL; Lu, YF; Zhang, Y; Zhang, YJ; Guo, Q; Gao, X; Cheng, YZ; Jiang, C or concate me.. Computed Properties of C4H14Cl2N2S2
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem