I found the field of Pharmacology & Pharmacy very interesting. Saw the article Investigation on vitamin e succinate based intelligent hyaluronic acid micelles for overcoming drug resistance and enhancing anticancer efficacy published in 2019.0. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride, Reprint Addresses Zhang, HJ; Zhang, ZZ (corresponding author), Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou, Henan, Peoples R China.; Zhang, HJ; Zhang, ZZ (corresponding author), Key Lab Targeting Therapy & Diag Crit Dis, Zhengzhou, Henan, Peoples R China.; Zhang, HJ; Zhang, ZZ (corresponding author), Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou, Henan, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride
Multidrug resistance (MDR) is a major reason for anticancer chemotherapy failure, and P-glycoprotein (P-gp) over-expressing on tumor cells is considered as the important target to overcome MDR. Emerging reports have showed that vitamin E (VE) can cause significant reversal of MDR due to inhibition of ATPase activity. Accordingly, we synthesized hyaluronic acid (HA) conjugated vitamin E succinate (VES) polymer, which can self-assemble into micelles and thus achieve high drug (paclitaxel (PTX) used as model drug) encapsulation as well as tumor accumulation owing to the enhanced permeability and retention (EPR) effect and HA active targeting ability. In addition, the linker between HA and VES utilized in this work was disulfide bond with reduction-sensitive property, which would respond to high glutathione (GSH) concentration in tumor cytoplasmic environment and trigger HA-CYS-VES polymer disassociation and drug release. In vitro, PTX loaded HA-CYS-VES demonstrated enhanced cytotoxicity, high apoptosis-inducing activities and reversal effects of PTX on MCF-7/Adr cells, compared to PTX. Also, cellular uptake and intracellular PTX accumulation tests displayed that PTX loaded HA-CYS-VES could more efficiently enter tumor cells and selectively release drug in cytosol so as to facilitate its function on microtubule. More importantly, PTX loaded HA-CYS-VES showed better tumor targeting ability, improved antitumor efficacy and low adverse effects on tumor-bearing mice. In conclusion, PTX loaded HA-CYS-VES exhibited a great potential for reversing MDR in anticancer chemotherapeutics.
About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Hou, L; Tian, CY; Chen, DD; Yuan, YJ; Yan, YS; Huang, QX; Zhang, HJ; Zhang, ZZ or concate me.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem