Day: October 11, 2021

Recommanded Product: 56-17-7. In 2020.0 BIOMACROMOLECULES published article about PERIODATE-OXIDATION; SERUM GALECTIN-3; CANCER; PECTIN; EXPRESSION; METASTASIS; INHIBITION; THERAPY; TUMORS; CELLS in [Subramanian, Suresh; Mallia, Madhava B.; Dash, Ashutosh] BARC, Radiopharmaceut Div, Mumbai 400085, Maharashtra, India; [Subramanian, Suresh; Mallia, Madhava B.; Dash, Ashutosh] Homi Bhabha Natl Inst, Mumbai 400094, Maharashtra, India; [Repaka, Krishnamohan] Board Radiat & Isotope Technol, Navi Mumbai 400703, India; [Balakrishnan, Biji; Kaur, Shahdeep; Chandan, Rajeet; Bhardwaj, Prateek; Banerjee, Rinti] Indian Inst Technol, Nanomed Lab, Dept Biosci & Bioengn, Mumbai 400076, Maharashtra, India in 2020.0, Cited 44.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Galectin-3 (gal-3) plays a crucial role in various cellular events associated to tumor metastasis and progression. In this direction, gal-3 binding core-shell glyconanoparticles based on citrus pectin (CP) have been designed for targeted, trigger-responsive combination drug delivery. Depolymerization via periodate oxidation in heterogeneous medium yielded low-molecular weight dialdehyde oligomers (CPDA) of CP with a gal-3 binding property (K-d = 160.90 mu M). CPDA-based core-shell nanoparticles prepared to enhance the gal-3 binding specificity via a multivalent ligand presentation have shown to reduce homotypic cellular aggregation, tumor cell binding with endothelial cells, and endothelial tube formation, the major steps involved in the progression of cancer. Immune-fluorescence and flow cytometric analysis confirmed significant reduction in gal-3 expression on MDA-MB 231 cancer cells upon incubation with nanoparticles. An on-demand tumor microenvironment-responsive release of drugs at low pH and high concentrations of glucose and glutathione prevailing in tumor milieu was achieved by introducing a cleavable Schiff’s base, a boronate ester, and disulfide linkages within the shell of the nanoparticles. Nanoparticles with encapsulated sulindac in the core and doxorubicin (DOX) in the shell demonstrated target specificity and enhanced internalization with synergistic cytotoxic effects with a 30-fold reduction in IC50 in DOX-resistant, triple-negative MDA-MB 231 breast cancer cells. Nanoparticles were radiolabeled with 131I radioisotopes with >= 80% efficiency while retaining its gal-3 binding property. Biodistribution studies of radiolabeled placebo nanoparticles and drug-loaded CPDA nanoparticles demonstrated proof of concept of gal-3 targeting seen as preferential accumulation in the gal-3-expressing tissues of the gastric tract. The CPDA core-shell nanoparticles are thus promising platforms for gal-3 targeting and inhibition of gal-3-mediated processes involved in cancer progression with a potential of radiolabeling for in vivo monitoring or delivering therapeutic doses of radiation and on-demand triggered, target-specific drug release.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Balakrishnan, B; Subramanian, S; Mallia, MB; Repaka, K; Kaur, S; Chandan, R; Bhardwaj, P; Dash, A; Banerjee, R or concate me.. Recommanded Product: 56-17-7

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Product Details of 56-17-7. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Self-assembled nanoparticles of reduction-sensitive poly (lactic-co-glycolic acid)-conjugated chondroitin sulfate A for doxorubicin delivery: preparation, characterization and evaluation published in 2019.0, Reprint Addresses Ren, J; Yu, JM (corresponding author), Jiujiang Univ, Sch Pharm & Life Sci, 320 Xunyang East Rd, Jiujiang 332000, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride.

In this study, reduction-sensitive self-assembled polymer nanoparticles based on poly (lactic-co-glycolic acid) (PLGA) and chondroitin sulfate A (CSA) were developed and characterized. PLGA was conjugated with CSA via a disulfide linkage (PLGA-ss-CSA). The critical micelle concentration (CMC) of PLGA-ss-CSA conjugate is 3.5 mu g/mL. The anticancer drug doxorubicin (DOX) was chosen as a model drug, and was effectively encapsulated into the nanoparticles (PLGA-ss-CSA/DOX) with high loading efficiency of 15.1%. The cumulative release of DOX from reduction-sensitive nanoparticles was only 34.8% over 96h in phosphate buffered saline (PBS, pH 7.4). However, in the presence of 20mM glutathione-containing PBS environment, DOX release was notably accelerated and almost complete from the reduction-sensitive nanoparticles up to 96h. Moreover, efficient intracellular DOX release of PLGA-ss-CSA/DOX nanoparticles was confirmed by CLSM assay in A549 cells. In vitro cytotoxicity study showed that the half inhibitory concentrations of PLGA-ss-CSA/DOX nanoparticles and free DOX against A549 cells were 1.141 and 1.825 mu g/mL, respectively. Therefore, PLGA-ss-CSA/DOX nanoparticles enhanced the cytotoxicity of DOX in vitro. These results suggested that PLGA-ss-CSA nanoparticles could be a promising carrier for drug delivery.

Product Details of 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Wang, XF; Ren, J; He, HQ; Liang, L; Xie, X; Li, ZX; Zhao, JG; Yu, JM or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about ORGANIC NANOPARTICLES; ENDOTHELIAL-CELLS; DRUG; PRODRUG; OXALIPLATIN; CISPLATIN; DESIGN; TUMOR; NANOMEDICINE; DELIVERY, Saw an article supported by the National Natural Science Funds of ChinaNational Natural Science Foundation of China (NSFC) [21602030, 81172993]; Shanghai Sailing Program [16YF1400900]; Scientific Research Foundation of Fudan University for Talent Introduction [JJF301103]; National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81425023]; Fudan-SIMM Joint Research Fund [FU-SIMM20174009]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Sun, T; Zhang, GP; Wang, QB; Guo, ZY; Chen, QJ; Chen, XL; Lu, YF; Zhang, Y; Zhang, YJ; Guo, Q; Gao, X; Cheng, YZ; Jiang, C. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. COA of Formula: C4H14Cl2N2S2

Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where a default supramolecular-dye couple was pre-blocked. The rational design, synthesis, characterization and proof-of-concept of this strategy were described in detail. The drug-release upon reducing environment can be translated into near-infrared (NIR) fluorescence signal (OFF-to-ON), allowing to track the drug-release procedure by multi-modal images including IVIS, FLECT and photoacoustic imaging. The versatile nanotheranostics system can target to triple negative breast tumor via conjugated F3 peptide, and show an improved anti-tumor efficacy with much lower side effect. The intelligent nanotheranostics system based on molecular shuttle provides new reference for precision medicine in preclinical trial and postclinical evaluation.

COA of Formula: C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Sun, T; Zhang, GP; Wang, QB; Guo, ZY; Chen, QJ; Chen, XL; Lu, YF; Zhang, Y; Zhang, YJ; Guo, Q; Gao, X; Cheng, YZ; Jiang, C or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Liu, WB; Kang, SM; Xu, XH; Zhou, L; Liu, N; Wu, ZQ in [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Hefei 230009, Anhui, Peoples R China; [Liu, Wen-Bin; Kang, Shu-Ming; Xu, Xun-Hui; Zhou, Li; Liu, Na; Wu, Zong-Quan] Hefei Univ Technol, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China published Controlled Synthesis of Shell Cross-Linked Helical Poly(phenylborate isocyanide) Nanoparticles with H2O2/Redox Dual Responsiveness and Their Application in Antitumor Drug Delivery in 2020.0, Cited 36.0. Category: thiazines. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

To mimic the helical structure and function of biopolymers, shell cross-linked nanoparticle (P4) composed of left-handed helical poly(phenylborate isocyanide) in core and hydrophilic polyisocyanide in shell was prepared. The phenylborate in the core and the disulfide bonds in the cross-linkage render the nanoparticle with excellent dual stimuli-responsiveness to glutathione (GSH) and H2O2. Nevertheless, it has good stability in normal physiological conditions. Because of the helicity and borate pendants of the core, such nanoparticle has high capacity for anticancer drug loading, for example, the loading capacity of doxorubicin (DOX) was up to 68%. Moreover, the DOX-loaded DOX@P4 showed excellent tumor cell penetration potency and fast drug release. More than 78% of murine breast cancer cell (4T1) can be killed within 48 h, supporting this material with great potential in antitumor drug nanocarriers.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Liu, WB; Kang, SM; Xu, XH; Zhou, L; Liu, N; Wu, ZQ or concate me.. Category: thiazines

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about DRUG-DELIVERY, Saw an article supported by the Key Research and Development Program of Shandong Province [2018CXGC1411]; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2015HM070]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Li, YM; Chen, XL; Ji, JB; Li, LB; Zhai, GX. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

In this paper, a novel redox-responsive nanoparticles has been designed for targeted delivery of docetaxel (DTX). Chondroitin sulfate (CS) was used to construct the nanoparticles due to the ability of tumor targeting through binding with CD44 receptor that overexpresses on the surfaces of various tumor cells. A redox-responsive small-molecular DTX prodrug was prepared through modifying with cystamine containing disulfide bonds (Cys-DTX). Then the DTX prodrug was grafted to the CS to construct the amphiphilic polymer (CS-ss-DTX). Further, Cys-DTX/CS-ss-DTX nanoparticles were formed by self-assembly of amphiphilic polymer and incorporation of free Cys-DTX prodrug. This category of nanosized DTX delivery system was expected for not only exhibiting high permeability and cytotoxicity of Cys-DTX prodrug, but also targeting transportation of encapsulated redox-responsive Cys-DTX prodrug. According to results of related researches on physicochemical properties and biological evaluation, the novel redox-responsive Cys-DTX/CS-ss-DTX nanoparticles increased amount of DTX released from the nanoparticles in reductive environment, improved permeability in tumor tissues, enhanced cytotoxicity and decreased side effects compared with free DTX. All of these results showed that this kind of Cys-DTX/CS-ss-DTX nanoparticles were worthy of being expectation in tumor chemotherapy in future.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Li, YM; Chen, XL; Ji, JB; Li, LB; Zhai, GX or concate me.. Application In Synthesis of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

I found the field of Science & Technology – Other Topics; Materials Science very interesting. Saw the article Controlled Synthesis of Shell Cross-Linked Helical Poly(phenylborate isocyanide) Nanoparticles with H2O2/Redox Dual Responsiveness and Their Application in Antitumor Drug Delivery published in 2020.0. COA of Formula: C4H14Cl2N2S2, Reprint Addresses Liu, N; Wu, ZQ (corresponding author), Hefei Univ Technol, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Hefei 230009, Anhui, Peoples R China.; Liu, N; Wu, ZQ (corresponding author), Hefei Univ Technol, Anhui Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China.. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

To mimic the helical structure and function of biopolymers, shell cross-linked nanoparticle (P4) composed of left-handed helical poly(phenylborate isocyanide) in core and hydrophilic polyisocyanide in shell was prepared. The phenylborate in the core and the disulfide bonds in the cross-linkage render the nanoparticle with excellent dual stimuli-responsiveness to glutathione (GSH) and H2O2. Nevertheless, it has good stability in normal physiological conditions. Because of the helicity and borate pendants of the core, such nanoparticle has high capacity for anticancer drug loading, for example, the loading capacity of doxorubicin (DOX) was up to 68%. Moreover, the DOX-loaded DOX@P4 showed excellent tumor cell penetration potency and fast drug release. More than 78% of murine breast cancer cell (4T1) can be killed within 48 h, supporting this material with great potential in antitumor drug nanocarriers.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Liu, WB; Kang, SM; Xu, XH; Zhou, L; Liu, N; Wu, ZQ or concate me.. COA of Formula: C4H14Cl2N2S2

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Recently I am researching about PERIODATE-OXIDATION; SERUM GALECTIN-3; CANCER; PECTIN; EXPRESSION; METASTASIS; INHIBITION; THERAPY; TUMORS; CELLS, Saw an article supported by the Science and Engineering Research Board Department of Science & Technology, MHRD, India [SB/FTP/ETA-202/2013]. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Balakrishnan, B; Subramanian, S; Mallia, MB; Repaka, K; Kaur, S; Chandan, R; Bhardwaj, P; Dash, A; Banerjee, R. The CAS is 56-17-7. Through research, I have a further understanding and discovery of 2,2′-Disulfanediyldiethanamine dihydrochloride

Galectin-3 (gal-3) plays a crucial role in various cellular events associated to tumor metastasis and progression. In this direction, gal-3 binding core-shell glyconanoparticles based on citrus pectin (CP) have been designed for targeted, trigger-responsive combination drug delivery. Depolymerization via periodate oxidation in heterogeneous medium yielded low-molecular weight dialdehyde oligomers (CPDA) of CP with a gal-3 binding property (K-d = 160.90 mu M). CPDA-based core-shell nanoparticles prepared to enhance the gal-3 binding specificity via a multivalent ligand presentation have shown to reduce homotypic cellular aggregation, tumor cell binding with endothelial cells, and endothelial tube formation, the major steps involved in the progression of cancer. Immune-fluorescence and flow cytometric analysis confirmed significant reduction in gal-3 expression on MDA-MB 231 cancer cells upon incubation with nanoparticles. An on-demand tumor microenvironment-responsive release of drugs at low pH and high concentrations of glucose and glutathione prevailing in tumor milieu was achieved by introducing a cleavable Schiff’s base, a boronate ester, and disulfide linkages within the shell of the nanoparticles. Nanoparticles with encapsulated sulindac in the core and doxorubicin (DOX) in the shell demonstrated target specificity and enhanced internalization with synergistic cytotoxic effects with a 30-fold reduction in IC50 in DOX-resistant, triple-negative MDA-MB 231 breast cancer cells. Nanoparticles were radiolabeled with 131I radioisotopes with >= 80% efficiency while retaining its gal-3 binding property. Biodistribution studies of radiolabeled placebo nanoparticles and drug-loaded CPDA nanoparticles demonstrated proof of concept of gal-3 targeting seen as preferential accumulation in the gal-3-expressing tissues of the gastric tract. The CPDA core-shell nanoparticles are thus promising platforms for gal-3 targeting and inhibition of gal-3-mediated processes involved in cancer progression with a potential of radiolabeling for in vivo monitoring or delivering therapeutic doses of radiation and on-demand triggered, target-specific drug release.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Balakrishnan, B; Subramanian, S; Mallia, MB; Repaka, K; Kaur, S; Chandan, R; Bhardwaj, P; Dash, A; Banerjee, R or concate me.. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Computed Properties of C4H14Cl2N2S2. In 2019.0 ACS BIOMATER SCI ENG published article about ANTIGEN; SIRNA; NANOPARTICLES; LIPOSOMES; NANOGELS; ADJUVANT; IMMUNITY; AMINE)S in [Yuan, Hongyuan; Yang, Yong; Xue, Wei; Liu, Zonghua] Jinan Univ, Key Lab Biomat, Guangdong Higher Educ Inst, Dept Biomed Engn, West Huangpu Rd 601, Guangzhou 510632, Guangdong, Peoples R China in 2019.0, Cited 23.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

Computed Properties of C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Yuan, HY; Yang, Y; Xue, W; Liu, ZH or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX in [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Peking Union Med Coll, Tianjin Key Lab Biomat, Inst Biomed Engn, Tianjin 300192, Peoples R China; [Zhang, Jing; Liu, Dan; Liu, Jiale; Leng, Xigang; Kong, Deling; Liu, Lanxia] Chinese Acad Med Sci, Tianjin 300192, Peoples R China; [Han, Yanfeng] Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW 2010, Australia; [Xu, Haiyan] Chinese Acad Med Sci, Inst Bas Sci, Sch Basic Med, Peking Union Med Coll, Beijing 100005, Peoples R China; [Kong, Deling] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China published Hybrid spherical nucleotide nanoparticles can enhance the synergistic anti-tumor effect of CTLA-4 and PD-1 blockades in 2020.0, Cited 25.0. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7.

Combined blockades of CTLA-4 and PD-1 can yield better overall complementary clinical outcomes than individual blockades, but the response rates are still relatively low. To investigate the anti-tumor effects of various combined strategies, we designed various spherical nucleotide nanoparticles (SNPs) loaded with CTLA-4 aptamer (cSNPs), PD-1 siRNA (pSNPs) or both (hybrid SNPs, or hSNPs). The results demonstrated that hSNPs could promote significantly stronger anti-tumor immune responses in a nonredundant fashion than the mixture of pSNPs and cSNPs (pSNPs & cSNPs). We reasoned that this is because all individual immune cells could receive both CTLA-4 and PD-1 blockades when they engulfed hSNPs, but it is much less likely that individual immune cells could receive both CTLA-4 and PD-1 blockades as many of them may not take both pSNPs and cSNPS from pSNPs & cSNPs. Further results revealed that the synergistic immune stimulatory effects of CTLA-4 and PD-1 blockades in the form of hSNPs were at least partly through regulating the immune suppressive function of both Tregs and TIM3(+)exhausted-like CD8 T cells and allowing effector T cells to expand. This mechanism is not identical to earlier reported mechanisms of CTLA-4 and PD-1 blockades.

About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Zhang, J; Liu, D; Liu, JL; Han, YF; Xu, HY; Leng, XG; Kong, DL; Liu, LX or concate me.. Safety of 2,2′-Disulfanediyldiethanamine dihydrochloride

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

In 2020.0 EUR POLYM J published article about POLY(AMIDOAMINE)-FUNCTIONALIZED GRAPHENE OXIDE; NANOPARTICLES; DESIGN; MULTIVALENT; REDUCTION; RELEASE in [Salami-Kalajahi, Mehdi; Roghani-Mamaqani, Hossein] Sahand Univ Technol, Fac Polymer Engn, POB 51335-1996, Tabriz, Iran; Sahand Univ Technol, Inst Polymer Mat, POB 51335-1996, Tabriz, Iran in 2020.0, Cited 60.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. Computed Properties of C4H14Cl2N2S2

Classic dendrimers are not used in many specific applications such as simultaneous loading of different drugs due to the existence of identical end groups. The possibility of designing the structure in dendrimers paves the way to synthesize more complicated dendrimers. This includes the creation of various types of peripheral groups on the surface of dendrimers to synthesize for example Janus dendrimers. Nowadays, three main methods are proposed for the synthesis of Janus dendrimers in which the high amount of conventional dendrimers is produced. The goal of this work is to develop a new method for synthesis of Janus dendrimers without production of conventional dendrimers. The present method has three main stages for the synthesis of Janus dendrimers including synthesis of 5th generation PPI dendrimer with cystamine core and hydrophobic surface, conversion of disulfide bonds to thiol group using a structure scission approach, and the formation of PAMAM hydrophilic dendrons with amine end groups. Different analyses including FT-IR, NMR, DLS, and GPC are used to prove the success of the synthesis route. Also, due to application of dendrimers in drug delivery including solubility improvement of hydrophobic drugs, Janus dendrimers are used to improve solubility of tetracycline and dexamethasone in presence of different generations of Janus dendrimers. Since the Janus dendrimers have both hydrophilic and hydrophobic ends, as well as having numerous terminal groups and numerous internal cavities, they have resulted in significant improvements in drug solubility. Also, solubility of the two hydrophobic drugs in water was increased by increasing concentration and generation of dendrimer.

Computed Properties of C4H14Cl2N2S2. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Najafi, F; Salami-Kalajahi, M; Roghani-Mamaqani, H or concate me.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem