In 2020.0 NAT NANOTECHNOL published article about POLY(PROPYLENE SULFIDE) NANOPARTICLES; DENDRITIC CELLS; ADAPTIVE IMMUNITY; CELLULAR-IMMUNITY; VIVO; TRANSPORT; PEPTIDES; ACTIVATION; MOLECULES; THERAPY in [Schudel, Alex; Francis, David Mark; Manspeaker, Margaret Patricia; Rohner, Nathan Andrew; Finn, M. G.; Thomas, Susan Napier] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA; [Schudel, Alex] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA; [Chapman, Asheley Poole; Yau, Mei-Kwan; Higginson, Cody James; Finn, M. G.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA; [Francis, David Mark; Manspeaker, Margaret Patricia] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA; [Avecilla, Alexa Regina Chua; Thomas, Susan Napier] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA; [Avecilla, Alexa Regina Chua; Thomas, Susan Napier] Emory Univ, Atlanta, GA 30322 USA; [Rohner, Nathan Andrew; Thomas, Susan Napier] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA; [Finn, M. G.; Thomas, Susan Napier] Georgia Inst Technol, Sch Biol Sci, Atlanta, GA 30332 USA; [Thomas, Susan Napier] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA in 2020.0, Cited 50.0. The Name is 2,2′-Disulfanediyldiethanamine dihydrochloride. Through research, I have a further understanding and discovery of 56-17-7. SDS of cas: 56-17-7
Therapeutic delivery selectively to lymph nodes has the potential to address a variety of unmet clinical needs. However, owing to the unique structure of the lymphatics and the size-restrictive nature of the lymph node reticular network, delivering cargo to specific cells in the lymph node cortex and paracortex is difficult. Here, we describe a delivery system to overcome lymphatic and intra-lymph node transport barriers by combining nanoparticles that are rapidly conveyed to draining lymph nodes after administration in peripheral tissues with programmable degradable linkers. This platform enables the controlled release of intra-lymph-mobile small-molecular cargo, which can reach vastly more immune cells throughout the lymph node than either the particles or free compounds alone. The release rate can be programmed, allowing access to different lymph node structures and therefore specific lymphocyte subpopulations. We are thus able to alter the subtypes of drugged lymph node cells to improve immunotherapeutic effects. Nanoparticles that access lymphatic vessels and are functionalized with degradable linkers, whose half-lives can be programmed, enable the controlled release of therapeutic cargo in different regions of the lymph nodes, allowing the targeting of otherwise difficult-to-reach lymphocyte subpopulations.
SDS of cas: 56-17-7. About 2,2′-Disulfanediyldiethanamine dihydrochloride, If you have any questions, you can contact Schudel, A; Chapman, AP; Yau, MK; Higginson, CJ; Francis, DM; Manspeaker, MP; Avecilla, ARC; Rohner, NA; Finn, MG; Thomas, SN or concate me.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem