A couple of challenges comes to mind: improving temperature dependence of relative stabilities of polymorphs would help in identifying enantiotropic relationships. 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, belongs to thiazines compound, is a common compound. In a pantent, author is Mir, Shafia, once mentioned the new application about 147118-35-2, Synthetic Route of 147118-35-2.
Synthetic Strategies of Benzothiazines: A Mini Review
Benzothiazine is a heterocyclic compound consisting of a benzene ring attached to the 6-membered thiazine ring. The benzothiazines constitute the group of heterocyclic compounds as they have found a variety of industrial uses and show promise as herbicides. Besides this, benzothiazines play an important role in the field of drug discovery as they have the potential to act as drug candidates for the treatment of a large number of diseases including, cancer, vasorelaxant, diabetic, hypertension, mycotic infection and microbial infection. The presence of nitrogen-sulphur axis and similarity in the structure with phenothiazine drugs help the benzothiazines to act as drugs for the treatment of a number of diseases. Herein, we represent different synthetic strategies for the simple and multi-component synthesis of benzothiazine heterocyclic derivatives. The strategies mostly involve the use of 2-aminothiophenol, 1, 3-dicarbonyl compounds or alpha-haloketones. In almost all the strategies, the potential yields have been obtained.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem