Aromatic rings are highly stable due to the arrangement of the π-electrons situated above and below the plane of the aromatic ring, which form a π-electron cloud. 139-65-1, Name is 4,4-Thiodianiline, belongs to thiazines compound, is a common compound, Name: 4,4-Thiodianiline.
Synthesis, Optimization, and Large-Scale Preparation of the Low Dose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3+2] Nitrone Cycloaddition
Herein we report a summary of the synthetic development of LY3202626 from the initial discovery route to a final route that was scaled to make 150 kg. Key developments include the use of a [3 + 2] cyclization to set the cis ring junction of the formed isoxazoline, a one-pot thiazine formation, and three different ways to install the aniline: (1) Cu-catalyzed azide coupling and reduction, (2) nitration and reduction, and (3) Buchwald coupling with acetamide.
By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 139-65-1. Name: 4,4-Thiodianiline.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem