Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, belongs to thiazines compound, is a common compound. In a pantent, author is Zieba, Andrzej, once mentioned the new application about 147118-35-2, Safety of (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate.
Application of Thin-Layer Chromatography to the Lipophilicity Analysis of Selected Anticancer Quinobenzothiazine Derivatives
The aim of this work was the application of thin-layer chromatography to the lipophilicity analysis of selected quinobenzothiazine derivatives. These are newly synthesized compounds, which were previously analyzed taking into consideration biological activity and their antiproliferative activity. Experimental lipophilicity parameters (R-M0 and log P-TLC) were determined by use of thin-layer chromatography, and also some theoretical values of lipophilicity were calculated by use of computer programs. The correlation between the experimental and the theoretical values of lipophilicity was found. Also, cluster analysis was performed for the data obtained. Phenothiazine derivatives were modified mainly by introduction of substituents into the nitrogen atom of the thiazine ring. The computer programs applied based on different theoretical approaches gave different values of lipophilicity parameters depending on the kind of substituent in the quinobenzothiazine system. None of the computer programs took into consideration the influence of substituents in a structure of the tested compounds, and in this case, the calculated lipophilicity parameter had the same value for all isomers with the same substituent. Also, none of the computer programs gave values of lipophilicity parameters close to these obtained by experimental method. The results of log P-calc for the compounds 1-13 were quite different according to the computer program used (log P-calc = 1.69-5.98). No computer programs gave values of log P-calc close to values of log P-TLC obtained experimentally. The reason can be the specific special structure of the tested phenothiazine derivatives consisting of tetracyclic system with additional nitrogen atom. It shows that calculation methods can be useless for the preliminary lipophilicity determination of such a kind of compounds.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem