In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. , Safety of 2-Chloro-10H-phenothiazine, 92-39-7, Name is 2-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS, belongs to thiazines compound. In a document, author is Winneroski, Leonard L., introduce the new discover.
Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
The BACE1 enzyme is a key target for Alzheimer’s disease. During our BACE1 research efforts, fragment screening revealed that bicyclic thiazine 3 had low millimolar activity against BACE1. Analysis of the co-crystal structure of 3 suggested that potency could be increased through extension toward the S3 pocket and through conformational constraint of the thiazine core. Pursuit of S3-binding groups produced low micromolar inhibitor 6, which informed the S3-design for constrained analogs 7 and 8, themselves prepared via independent, multi-step synthetic routes. Biological characterization of BACE inhibitors 6-8 is described. (C) 2015 Elsevier Ltd. All rights reserved.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 92-39-7. The above is the message from the blog manager. Safety of 2-Chloro-10H-phenothiazine.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem