Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, belongs to thiazines compound, is a common compound. In a pantent, author is Le, Tam Minh, once mentioned the new application about 147118-35-2, Electric Literature of 147118-35-2.
Synthesis and Transformation of (-)-Isopulegol-Based Chiral -Aminolactones and -Aminoamides
A library of isopulegol-based -amino acid derivatives has been developed from commercially-available (-)-isopulegol. Michael addition of primary and secondary amines towards ,-unsaturated -lactones was accomplished resulting in -aminolactones in highly-stereoselective reactions. Ring-opening of -aminolactones with different amines furnished excellent yields of -aminoamides. Moreover, the applicability of aminolactones in peptide synthesis was examined by opening the lactone ring with – and -aminoesters, providing dipeptides as promising chiral substrates for the synthesis of foldamers. The antiproliferative activities of -aminolactones and -aminoamides were explored, and the structure-activity relationships were studied from the aspects of the stereochemistry of the monoterpene ring and the substituent effects on the -aminoamide ring system. The N-unsubstituted (-)-isopulegol-based -aminoamides exhibited considerable antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF7 and MDA-MB-231).
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 147118-35-2 is helpful to your research. Electric Literature of 147118-35-2.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem