When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. , Quality Control of 4′-(Methylsulfonyl)acetophenone, 10297-73-1, Name is 4′-(Methylsulfonyl)acetophenone, molecular formula is C9H10O3S, belongs to thiazines compound. In a document, author is Chauhan, Nilesh B., introduce the new discover.
Synthesis and biological evaluation of coumarin clubbed thiazines scaffolds as antimicrobial and antioxidant
A new series of 4-methyl-6-nitro-2-oxo-2H-chroman-7yl-2-(4-(4-fluorophenyl)-6-phenyl-2H-1,3-thiazin-2-yl-amino)acetates 5a-j were synthesized from 6-nitro-4-methyl coumarinyl chloroacetate (5) and 2-amino thiazines (IIIa-j). The structure of the final compounds was adequately confirmed via spectroscopic techniques (IR, H-1 NMR, C-13 NMR, Mass) and characterization of physical properties. Final compounds were screened for their antimicrobial, antitubercular, and antioxidant activities. Compounds 5c and 5h found to have antibacterial potency against E. coli with MIC values 50 mu g/mL compared to standard drugs. Compound 5d demonstrated better antifungal potency (MIC = 200 mu g/mL) against C. albicans when compared with griseofulvin. Compounds 5b and 5h found to be encouraging antitubercular (MIC = 62.5 mu g/mL with 98-99% inhibition) against M. tuberculosis H(37)Rv. The newly synthesized 5h and 5b were appeared to have high radical scavenging efficacies as 33.99 +/- 0.301 and 35.35 +/- 0.470 mu g/mL +/- SD of IC50 values, respectively, in DPPH and ABTS bioassay.
Quality Control of 4′-(Methylsulfonyl)acetophenone, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 10297-73-1.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem