Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Application In Synthesis of 2-Chloro-10H-phenothiazine, 92-39-7, Name is 2-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS, belongs to thiazines compound. In a document, author is Ghoneim, Amira A., introduce the new discover.
Design, synthesis and anticancer evaluation of novel thiazine, pyrimidine and pyridine derivatives
Acylisothiocyanate (1) was allowed to react with benzylidenemalononitrile producing oxazine derivative (2). Also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). The reaction of acetylacetone with compound (1) gave pyridine derivative (5) by intramolecularcycloaddition while it was reacted with N-methyl aniline affording thiazine derivative (7). In addition, it was reacted with cyanoacetamide producing mercaptopyrimidine derivative (9). Finally, compound (1) was refluxed with phenylhydrazine, urea, guanidmum carbonate and anthranilic acid in the presence of dry acetone affording triazole derivative (11), N-substituted pyrimidine (15), compound (18) and thiopyrimidine derivative (19) respectively. The structures of the new compounds were confiimed on the basis of elemental and spectral data. Some of the synthesized compounds were screened as anticancer.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 92-39-7. Application In Synthesis of 2-Chloro-10H-phenothiazine.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem