When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. , Synthetic Route of 92-30-8, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Dar’in, Dmitrii, introduce the new discover.
Realizing the Trifunctional Potential of Alkyl 4-Chloro-2-diazo-3-oxobutanoates: Convenient Assembly of 6,7-Dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]thiazine Core
The first example of exploiting the trifunctional character of alkyl 4-chloro-2-diazo-3-oxobutanoates in the reactions with vicinal N , S -bis-nucleophiles leading to the formation of bicyclic 6,7-dihydro-4 H -[1,2,3]triazolo[5,1- c ][1,4]thiazines is presented. The key to the successful realization of the atom-economical synthetic strategy is the initial S (N) 2 event, which facilitates the subsequent domino 1,2,3-triazole formation via the Wolff reaction. Equally important is the choice of sodium acetate as the base: acetic acid formed in the course of the initial nucleophilic substitution acts as an efficient catalyst for the Wolff reaction, which suppresses the competing, unwanted fragmentation path (observed when other bases are used).
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem