Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 5326-23-8, Name is 6-Chloronicotinic acid, belongs to thiazines compound, is a common compound. In a pantent, author is Kumar, Pankaj, once mentioned the new application about 5326-23-8, Safety of 6-Chloronicotinic acid.
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL OXAZOLIDINONES HAVING BENZO THIAZINE DERIVATIVES
In order to develop relatively small molecules as pharmacologically active molecules, a series of novel oxazolidinones having benzothiazine and their derivatives were synthesized and characterized by IR, H-1 NMR and Mass spectral studies. Various substituted oxazolidinone benzothiazines were prepared by simple refluxing in the presence of acetonitrile. Treatment of these oxazolidinone benzothiazine derivatives with methanesulfonyl chloride gives its sulphonate derivatives which on further treatment with sodium azide and triphenyl phosphine in acetic anhydride gave acetamide derivatives. Further the synthesized compounds were evaluated for antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against Candida albicans and Aspergillus niger.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem