Research speed reading in 2021. Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. , HPLC of Formula: https://www.ambeed.com/products/147118-35-2.html, 147118-35-2, Name is (R)-Methyl 3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate, molecular formula is C31H39O4PSi, belongs to thiazines compound. In a document, author is Sirakanyan, Samvel N., introduce the new discover.
On the reactivity of pyrido[3 ‘,2 ‘:4,5]furo(thieno)[3,2-d]pyrimidin-7(8)-ones with some alkyl mono- and di-halides: synthesis of new heterocyclic systems containing thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b]thiazine moiety
Ethyl 1-aminofuro(thieno)[2,3-b]pyridine-2-carboxylates 1 reacted with benzoyl isothiocyanate and gave the relevant thioureido derivatives 2, whose intramolecular cyclization under the action of potassium hydroxide furnished the relevant 9(10)-thioxopyrido[3′,2′:4,5]furo(thieno)[3,2-d]pyrimidin-7(8)-ones 3. Compounds 3 with methyl iodide could give the S-methyl 4 and S,N-dimethyl 5 derivatives. Interestingly 3 by alkylation with alkyl dichlorides (bifunctional reagents) the cyclization to a thiazoline or to a thiazine ring on the [a] side of the pyrimidine ring occurs, with formation of the new pentacyclic systems: furo(thieno)[3,2-d][1,3]thiazolo[3,2-a]pyrimidin-7(8)-ones 6 and furo(thieno)[3′,2’:4,5]pyrimido[2,1-b] [1,3]thiazin-7(8)-ones 7. Moreover compounds 3 by alkylation with p-chlorophenacyl bromide (again a bifunctional reagent) led to the formation of the corresponding S-alkylated compounds 9, whose cyclization furnished structural analogues of compounds 6: p-chlorophenyl-substituted thiazolo[3,2-a] pyrimidin-7(8)-ones 10. The structure of the obtained compounds has been unambiguously confirmed by using a wide spectrum of physico-chemical methods and, in the instance of compounds 6 and 7, also by an alternative synthesis via a double-annelation reaction using a BMMA reagent. Biological tests have shown promising antimicrobial activity against Staphylococcus aureus for some of the synthesized compounds. (C) 2015 Elsevier Ltd. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 147118-35-2, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/147118-35-2.html.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem