New Advances in Chemical Research, May 2021.Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 20277-69-4, Name is Sodium methanesulfinate, belongs to thiazines compound, is a common compound. In a pantent, author is Cilliers, Cornelius, once mentioned the new application about 20277-69-4, Safety of Sodium methanesulfinate.
Residualization Rates of Near-Infrared Dyes for the Rational Design of Molecular Imaging Agents
Near-infrared (NIR) fluorescence imaging is widely used for tracking antibodies and biomolecules in vivo. Clinical and preclinical applications include intraoperative imaging, tracking therapeutics, and fluorescent labeling as a surrogate for subsequent radiolabeling. Despite their extensive use, one of the fundamental properties of NIR dyes, the residualization rate within cells following internalization, has not been systematically studied. This rate is required for the rational design of probes and proper interpretation of in vivo results. In this brief report, we measure the cellular residualization rate of eight commonly used dyes encompassing three core structures (cyanine, boron-dipyrromethene (BODIPY), and oxazine/thiazine/carbopyronin). We identify residualizing (half-life > 24 h) and non-residualizing (half-life < 24 h) dyes in both the far-red (similar to 650-680 nm) and near-infrared (similar to 740-800 nm) regions. This data will allow researchers to independently and rationally select the wavelength and residualizing nature of dyes for molecular imaging agent design. Safety of Sodium methanesulfinate, In the meantime we’ve collected together some recent articles in this area about 20277-69-4 to whet your appetite. Happy reading!
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem