Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. , Synthetic Route of 92-30-8, 92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, molecular formula is C13H8F3NS, belongs to thiazines compound. In a document, author is Niu Liping, introduce the new discover.
Synthesis of the Fused Tetracyclic Thiazinan-4-one Derivatives and Their Anti-tumor Activitiy
The benzothiazin-4-one intermediates were prepared by the one-pot three-components condensation from the N-Boc-L-prolinal 1, amino acid ethyl/methyl ester hydrochlorides 2a similar to 2d, and mercaptobenzoic acids 3a similar to 3b. After removal of Boc, the target novel fused tetracyclic thiazinan-4-one derivatives 6 similar to 11 were afforded by the intramolecular cyclo- amidation reaction. The absolute configurations of the newly generated chiral carbon (1-C) were determined by the coupling constants of H-1 and H-2 and the X-ray crystallographic structures. The tetracyclic alkaloids were examined for their anti-proliferative activity against Hela and A549 tumor cells. The results showed that some compounds could moderately inhibit the growth of Hela cells, and among them, (13aR, 13bR)-1,2,3,13b-tetrahydrobenzo[e]pyrrolo[2′, 1′: 3,4] pyrazino[2,1b][1,3] thiazine-5,8(6H, 13aH)-dione (6b) was the best one with the IC50 value of 9.50 mu mol/L. However, all the compounds showed no anti-tumor activity against A549.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem