Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 5326-23-8, Name is 6-Chloronicotinic acid, belongs to thiazines compound, is a common compound. In a pantent, author is Ashraf, Adnan, once mentioned the new application about 5326-23-8, SDS of cas: 5326-23-8.
Ru-II(eta(6)-p-cymene) Complexes of Bioactive 1,2-Benzothiazines: Protein Binding vs. Antitumor Activity
1,2-Benzothiazine-3-carboxamide 1,1-dioxide derivatives such as meloxicam are known to display numerous pharmacological activities. We prepared a series of 4-hydroxy-2-alkyl-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide ligands 1a-f and their Ru((6)-p-cymene) complexes 2a-f, inspired by synergistic effects observed with other bioactive ligands coordinated to metal centres. The molecular structures of 1a, 2a, and 2b were determined by X-ray diffraction analyses. The stability of the metal complexes was characterized in DMSO and DMSO/H2O on the basis of H-1 NMR spectroscopy and their protein binding capabilities were studied using mass spectrometry. In vitro cytotoxicities of the Ru complexes were determined against human colorectal carcinoma (HCT116), non-small cell lung carcinoma (NCI-H460) and cervical carcinoma (SiHa) cell lines. The low levels of biological activity observed for these Ru complexes were put into context by considering their chemical reactivity with proteins. The binding of proteins resulted in cleavage of the benzothiazine backbone when the complex was present in concentrations equimolar with respect to protein.
The proportionality constant is the rate constant for the particular unimolecular reaction. You can get involved in discussing the latest developments in this exciting area about 5326-23-8. SDS of cas: 5326-23-8.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem