New Advances in Chemical Research, May 2021.The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. 139-65-1, Name is 4,4-Thiodianiline, belongs to thiazines compound, is a common compound. In a pantent, author is Wang Wen-Bin, once mentioned the new application about 139-65-1, Related Products of 139-65-1.
Synthesis, Crystal Structure and Cytotoxic Activities of 1-(Prop-2-yn-1-yl)-7,8-dihydro-1H-benzo[d][1,3]-thiazine-2,5(4H,6H)-dione Derivatives
The important synthetic precursor (III), 1-(prop-2-yn-1-yl)-7,8-dihydro-1H-benzo[d][1,3]thiazine-2,5(4H,6H)-dione (C11H11NO2S), was prepared through a three-component reaction, which was further transferred into cytotoxic triazoles by alkylation and click synthesis in satisfactory yields of 87%similar to 95%. Their structures were characterized by IR, H-RESI-MS and NMR analysis. Meanwhile, the crystal of III was obtained and determined by X-ray single-crystal diffraction. Crystal data: orthorhombic system, space group P2(1)2(1)2(1), a = 5.189(4), b = 8.661(6), c = 23.498(17) angstrom, V = 1056.2(13) angstrom(3), Z = 4, F(000) = 464, D-c = 1.392 g/cm(3), mu = 0.284 mm(-1), R = 0.0637 and wR = 0.1668 for 8182 independent reflections (R-int = 0.1580) and 2166 observed ones (I>2 sigma(1)).
Related Products of 139-65-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 139-65-1 is helpful to your research.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem