Research speed reading in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, nano-ceramics,and research on the structure and performance of functional materials. , Reference of 154445-78-0, 154445-78-0, Name is 2,2,4,6,7-Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride, molecular formula is C13H17ClO3S, belongs to thiazines compound. In a document, author is Artym, Jolanta, introduce the new discover.
Selected azaphenothiazines inhibit delayed type hypersensitivity and carrageenan reaction in mice
Several, previously selected azaphenothiazines, as strongly antiproliferative agents in in vitro models, were subjected to evaluation for their potential immunosuppressive effects in the model of delayed type hypersensitivity (DTH) to ovalbumin (OVA) in BALB/c mice and in foot pad inflammation induced by carrageenan in CBA mice. In the DTH model the compounds were given to mice intraperitoneally (i.p.) in 50 mu g or 250 mu g doses, 1 h before the elicitation of the response. In the carrageenan-induced foot pad inflammation the compounds were given i.p. in 50 mu g or 250 mu g doses, 24 h and 2 h before administration of carrageenan. Among the compounds, the significantly suppressive activities in both models were exhibited only by compound 5 (6-chloroethylureidoethyldiquino[3,2-b;2′,3′-e][1,4]thiazine) and compound 4 (6-acetylaminobuty1-9-chloroquino[3,2-blbenzo[1,4]thiazine). Structure-activity relationship, plausible mechanism of action and potential application in therapy of the compounds are discussed. (C) 2016 Elsevier B.V. All rights reserved.
Reference of 154445-78-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 154445-78-0.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem