Research speed reading in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.. , Quality Control of 2-Chloro-10H-phenothiazine, 92-39-7, Name is 2-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS, belongs to thiazines compound. In a document, author is Winneroski, Leonard L., introduce the new discover.
Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
The BACE1 enzyme is a key target for Alzheimer’s disease. During our BACE1 research efforts, fragment screening revealed that bicyclic thiazine 3 had low millimolar activity against BACE1. Analysis of the co-crystal structure of 3 suggested that potency could be increased through extension toward the S3 pocket and through conformational constraint of the thiazine core. Pursuit of S3-binding groups produced low micromolar inhibitor 6, which informed the S3-design for constrained analogs 7 and 8, themselves prepared via independent, multi-step synthetic routes. Biological characterization of BACE inhibitors 6-8 is described. (C) 2015 Elsevier Ltd. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 92-39-7, you can contact me at any time and look forward to more communication. Quality Control of 2-Chloro-10H-phenothiazine.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem