Day: April 30, 2021

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. , Category: thiazines, 66-27-3, Name is Methyl methanesulfonate, molecular formula is C2H6O3S, belongs to thiazines compound. In a document, author is Haggam, Reda A., introduce the new discover.

Facile synthesis of some condensed 1,3-thiazines and thiazoles under conventional conditions: antitumor activity

1,3-Thiazine 3 was obtained from cinnamoyl thiourea derivative 2 as the kinetic control product. Refluxing of 2 with sodium ethoxide afforded pyrimidine derivative 4. Moreover, stirring of 2 with bromine/acetic acid gave thiazole 5 that was condensed with o-phenylene diamine forming benzimidazole 6. Heating of arylthiourea 8 with maleic anhydride or phenacyl chloride afforded thiazole derivatives 9 and 10, respectively. Condensation of compound 10 with o-phenylene diamine gave benzimidazole 11. Reaction of p-amino benzoic acid with chloro acetyl isothiocyanate, acetylacetone and ethylacetoacetate produced imidazole 14, enaminone 15 and crotonate 16 derivatives, respectively. Stirring a mixture of benzoyl isothiocyanate with 15 and/or 16 resulted in pyridine-2-thione 17. The yields of the prepared compounds were 41-93%. The experimental section is simple and easy. The detailed synthesis, spectroscopic data, IC50 and antitumor activity of the synthesized compounds were reported. The cytotoxicity of the newly synthesized products showed that compound 4 is the most active compound towards the cancer cell line at which its reactivity is higher than that of the standard doxorubicin (anticancer reference drug).

If you are interested in 66-27-3, you can contact me at any time and look forward to more communication. Category: thiazines.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 7143-01-3, Name is Methanesulfonic anhydride, belongs to thiazines compound, is a common compound. In a pantent, author is Yennawar, Hemant P., once mentioned the new application about 7143-01-3, Recommanded Product: Methanesulfonic anhydride.

Crystal structures of two 2,3-diary1-2,3-dihydro-4H1,3-benzothiazin-4-ones

The syntheses and crystal structures of 2,3-bis[3-(trifluoromethyl)phenyl]-2,3dihydro-4H-1,3-benzothiazin-4-one (di-m-CF3; C22H13F6NOS) (1) and 2,3-bis(4-methylphenyl)-2,3-dihydro-4H-1,3-benzothiazin-4-one (di-p-CH3; C22H9NOS) (2) are reported. Each structure is racemic: the asymmetric unit of 2 consists of two molecules. In both 1 and 2, the six-membered 1,3-thiazine ring is close to an envelope conformation with the chiral C atom forming the flap. In 1, the 2-aryl group is pseudo-equatorial, while in 2 it is pseudo-axial. In 1, the pendant aryl rings form a V shape with an inter-centroid distance of 3.938 (3) A and an acute dihedral angle of 48.3 (2) between them. Both CF3 groups are disordered over two orientations in 0.687 (19):0.313 (19) and 0.667 (16):0.33 (16) ratios. In each of the independent molecules of 2, the aryl rings are almost orthogonal to each other [dihedral angles = 85.50 (12) and 86.07 (11) I. In both structures, the chiral C atom and the 0 atoms participate in C-H center dot center dot center dot O-type hydrogen bonding between symmetry-related molecules of 1 or the independent enantiomers in 2, forming chains along the c-axis direction in 1 and the b-axis direction in 2. Additionally, in 1, pi-pi contacts of both face-to-face and edge-to-face type, as well as pi-H center dot center dot center dot O and pi-H center dot center dot center dot F interactions are observed. In 2, a racemic mixture of molecules forms layers in the ac plane linked by weak pi-pi and C-H center dot center dot center dot pi interactions.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 7143-01-3 is helpful to your research. Recommanded Product: Methanesulfonic anhydride.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 110553-27-0, Name is 2-Methyl-4,6-bis((octylthio)methyl)phenol, belongs to thiazines compound, is a common compound. In a pantent, author is Gomha, Sobhi M., once mentioned the new application about 110553-27-0, Recommanded Product: 110553-27-0.

SYNTHESIS OF SOME NOVEL THIAZOLE, THIADIAZOLE AND 1,4-PHENYLENE-BIS-THIAZOLE DERIVATIVES AS POTENT ANTITUMOR AGENTS

A novel series of 2-ethylidenehydrazono-5-arylazothiazoles 5a-h and 2-ethylidenehydrazono-5-arylazothiazolones 9a-d were prepared by cyclocondensation of hydrazonyl halides 3a-h and 7a-d with ethylidenethiosemicarbazide 2. In addition, reaction of 2 with N-phenyl-carbohydrazonyl chloride (14), afforded 1,3,4-thiadiazole derivative 17 as the end product. Moreover, the thiosemicarbazide derivative 2 was reacted with various bromoacetyl compounds 19a-d and 1,1′-(1,4-phenylene)bis(2-bromoethanone) (21) furnished the respective thiazole derivatives 20a-d and 1,4-phenylene-bis-thiazole derivative 22. The structures of the newly synthesized compounds were established on the basis of spectroscopic evidences and their alternative syntheses. The newly synthesized compounds were evaluated for their antitumor activities against hepatocellular carcinoma (HepG2) cell line and the results revealed promising activities of compounds 5h, 5d, 5g, 5f and 5e with IC50 equal 2.23 +/- 0.28, 2.48 +/- 0.34, 2.49 +/- 0.24, 4.03 +/- 0.11, and 5.32 +/- 0.27 mu M, respectively.

Interested yet? Read on for other articles about 110553-27-0, you can contact me at any time and look forward to more communication. Recommanded Product: 110553-27-0.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. , Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride, 56-17-7, Name is 2,2′-Disulfanediyldiethanamine dihydrochloride, molecular formula is C4H14Cl2N2S2, belongs to thiazines compound. In a document, author is Imperatore, Concetta, introduce the new discover.

Exploring the antimalarial potential of the methoxy-thiazinoquinone scaffold: Identification of a new lead candidate

A small library of antiplasmodial methoxy-thiazinoquinones, rationally designed on the model of the previously identified hit 1, has been prepared by a simple and inexpensive procedure. The synthetic derivatives have been subjected to in vitro pharmacological screening, including antiplasmodial and toxicity assays. These studies afforded a new lead candidate, compound 9, endowed with higher antiplasmodial potency compared to 1, a good selectivity index when tested against a panel of mammalian cells, no toxicity against RBCs, a synergistic antiplasmodial action in combination with dihydroartemisinin, and a promising inhibitory activity on stage V gametocyte growth. Computational studies provided useful insights into the structural requirements needed for the antiplasmodial activity of thiazinoquinone compounds and on their putative mechanism of action.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 56-17-7. Quality Control of 2,2′-Disulfanediyldiethanamine dihydrochloride.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Application of 196597-78-1, In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate.196597-78-1, Name is 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one, SMILES is O=C1CCC2=CC=C3OCCC3=C12, belongs to thiazines compound. In a article, author is Urbanaite, Aurelija, introduce new discover of the category.

Electrophile-Mediated Reactions of Functionalized Propargylic Substrates

Metal-free halogen, chalcogen, or oxocarbenium ion mediated yne-carbonyl or yne-thioxo transformations of a range of N- and O-propargylic compounds have been studied. This investigation has led to the development of a mild, economic, and effective method for the synthesis of functionalized 4H-1,3-oxazines, 4H-1,3-thiazines, 4,5-dihydrothiazoles, and alpha-substituted enones. The structure of the propargylic substrate and the nature of electrophile influence both the outcome and regioselectivity of processes.

Application of 196597-78-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 196597-78-1 is helpful to your research.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 139-65-1, Name is 4,4-Thiodianiline, molecular formula is C12H12N2S. In an article, author is Belskaya, Nataliya P.,once mentioned of 139-65-1, COA of Formula: C12H12N2S.

1,3-Dipolar cycloaddition of 3-alkylsulfanyl-2-arylazo-3-(tert-cycloalkylamino)acrylonitriles with N-methyl- and N-phenylmaleimides

A series of 1,2-diaza-1,3-butadienes with terminal S,N-acetal function were obtained and reacted with N-methyl- and N-phenylmaleimides. As a result of the 1,3-dipolar cycloaddition, a range of new functionalized nonaromatic heterocyclic compounds including: octahydro-1H-pyrrolo[3,4-a]indolizine, octahydropyrrolo[3′,4′:3,4]pyrrolo[1,2-a]azepine, hexahydropyrrolo[3′,41:3,4]pyrrolo[2,1-c][1,4]oxazine and -thiazine, were obtained with good yields in mild conditions. Experimental and theoretic results allowed establishment of a relationship between the structures of the tert-cycloallcylamine group and the activity of the azomethine ylides generated. (C) 2014 Elsevier Ltd. All rights reserved.

If you are interested in 139-65-1, you can contact me at any time and look forward to more communication. COA of Formula: C12H12N2S.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 196597-78-1, Name is 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one, molecular formula is , belongs to thiazines compound. The appropriate choice of redox mediator can avoid electrode passivation and overpotential.In a document, author is Mishima, Naoya, HPLC of Formula: C11H10O2.

Synthesis of Thiazinoimidazoles by Lewis Acid-Catalyzed [3+3] Cycloaddition Reactions of Propargyl Alcohols with 2-Mercaptoimidazoles

The unique ytterbium-catalyzed generation of sulfur- and selenium-substituted propargylic and allenic cations and their reactions with 2-mercaptoimidazole derivatives were described. The regioselective [3+3] annulation reactions proceeded to give a wide variety of S,N-acetal-containing bicyclic and tricyclic thiazinoimidazoles in good to high yields. Treatment of thiazinoimidazoles with LDA readily underwent ring contraction to afford thiazolobenzimidazoles. Deselenenylation and successive functionalization broaden the scope of accessible thiazinoimidazoles.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 196597-78-1. HPLC of Formula: C11H10O2.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 66-27-3, Name is Methyl methanesulfonate, molecular formula is , belongs to thiazines compound. In a document, author is Milburn-McNulty, P., Recommanded Product: Methyl methanesulfonate.

Sulthiame add-on therapy for epilepsy

Background Epilepsy is a common neurological condition characterised by recurrent seizures. Most patients respond to conventional antiepileptic drugs, however, around 30% will continue to experience seizures despite multiple antiepileptic drugs. Sulthiame, also known as sultiame, is a widely used antiepileptic drug in Europe and Israel. We present a summary of the evidence for the use of sulthiame as add-on therapy in epilepsy. Objectives To compare the efficacy and side-effect profile of sulthiame as add-on therapy compared with placebo or another antiepileptic drug. Search methods We searched the Cochrane Epilepsy Group’s Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, ClinicalTrials.gov and the WHO ICTRP Search Portal on 11 August 2015. No language restrictions were imposed. We contacted the manufacturers of sulthiame and researchers in the field to seek any ongoing or unpublished studies. Selection criteria Randomised controlled add-on trials of sulthiame in people of any age with epilepsy of any aetiology. Data collection and analysis Two review authors independently selected trials for inclusion and extracted relevant data. The following outcomes were assessed: 1) reduction in seizure frequency of 50% or greater between baseline and end of follow-up; 2) complete cessation of seizures during follow-up; 3) mean seizure frequency; 4) time to treatment withdrawal; 5) adverse drug effects; and 6) quality of life scoring. Primary analyses were intention-to-treat. We present a narrative analysis. Main results We included one trial with 37 participants with a new diagnosis of West syndrome. Sulthiame was given as an add-on therapy to pyridoxine. No data were reported for outcomes 1), 3) or 6). Overall risk ratio with 95% confidence intervals (CI) for complete cessation of seizures during a nine-day follow-up period versus placebo was 0.71 (95% CI 0.53 to 0.96). Meaningful analysis of time to treatment withdrawal and adverse drug effects was not possible due to incomplete data. Authors’ conclusions Sulthiame may lead to a cessation of seizures when used as an add-on therapy to pyridoxine in patients with West syndrome. The included study was small and had a significant risk of bias which limits the impact of the evidence. No conclusions can be drawn about the occurrence of adverse drug effects, change in quality of life or mean reduction in seizure frequency. No evidence exists for the use of sulthiame as an add-on therapy in patients with epilepsy outside West syndrome. Large, multi-centre randomized controlled trials are necessary to inform clinical practice if sulthiame is to be used as an add-on therapy for epilepsy.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 66-27-3, you can contact me at any time and look forward to more communication. Recommanded Product: Methyl methanesulfonate.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

Chemistry is a science major with cience and engineering. , HPLC of Formula: C7H10O4S, The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials.Introducing a new discovery about 6192-52-5, Name is 4-Methylbenzenesulfonic acid hydrate, molecular formula is C7H10O4S, belongs to thiazines compound. In a document, author is Sebbar, Nada Kheira.

Crystal structure, Hirshfeld surface analysis and interaction energy and DFT studies of (2Z)-4-benzyl-2-(2,4-dichlorobenzylidene)-2H-1,4-benzothiazin-3(4H)-one

The title compound, C22H15Cl2NOS, contains 1,4-benzothiazine and 2,4-dichlorobenzylidene units, where the dihydrothiazine ring adopts a screw-boat conformation. In the crystal, intermolecular C-H-Bnz center dot center dot center dot O)(Thz) (Bnz = benzene and Thz = thiazine) hydrogen bonds form corrugated chains extending along the b-axis direction which are connected into layers parallel to the be plane by intermolecular C-H-Methy center dot center dot center dot S-Thz (Methy = methylene) hydrogen bonds, enclosing R-4(4)(22) ring motifs. Offset pi-stacking interactions between 2,4-dichlorophenyl rings [centroid-centroid = 3.7701 (8) angstrom] and pi-interactions which are associated by C-H-Bnz center dot center dot center dot pi(ring) and C-H-Dehlphy center dot center dot center dot pi(ring) (Dchlphy = 2,4-dichlorophenyl) interactions may be effective in the stabilization of the crystal structure. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H center dot center dot center dot H (29.1%), H center dot center dot center dot C/C center dot center dot center dot H (27.5%), H center dot center dot center dot Cl/Cl center dot center dot center dot H (20.6%) and O center dot center dot center dot H/H center dot center dot center dot O (7.0%) interactions. Hydrogen-bonding and van der Waals interactions are the dominant interactions in the crystal packing. Computational chemistry indicates that in the crystal, the C-H-Bnz center dot center dot center dot O-Thz and C-H-Methy center dot center dot center dot S-Thz hydrogen-bond energies are 55.0 and 27.1 kJ mol(-1), respectively. Density functional theory (DFT) optimized structures at the B3LYP/6-311G(d,p) level are compared with the experimentally determined molecular structure in the solid state. The HOMO-LUMO behaviour was elucidated to determine the energy gap.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6192-52-5 is helpful to your research. HPLC of Formula: C7H10O4S.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem

 

In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 139-65-1, Name is 4,4-Thiodianiline, molecular formula is , belongs to thiazines compound. In a document, author is El-Sayed, Hassan A., COA of Formula: C12H12N2S.

NOVEL SYNTHESIS, RING TRANSFORMATION AND ANTICANCER ACTIVITY OF 1,3-THIAZINE, PYRIMIDINE AND TRIAZOLO[1,5-a]PYRIMIDINE DERIVATIVES

Synthesis, heterocyclization and anticancer activity of a new series of heterocyclic compounds are described. Aminothiazine 1 was obtained from the base induced condensation of thiourea, benzaldehyde and ethyl cyanoacetate. The synthesis of N-phenyl amino pyrimidine derivative 2 was obtained as a result of reaction of aniline with compound 1. Compound 2 underwent ring opening and recyclization upon reaction with HCl or H2O2/NaOH to afford the acid derivative 3 or oxazine 4, respectively. Thiazine 1 undergoes ring transformation upon the effect of NH2OH center dot HCl to produce pyrimidine derivative 5. Heterocyclization of compound 1 with thiosemicarbazide followed by oxidation with I-2/AcOH afforded triazolopyrimidine 6 and 7, respectively. Alkylation of compound 1 was promoted by reaction of 1 with ethyl iodide to give alkylated thiazine 8 which in turn undergo ring transformation when subjected to reaction with hydrazine hydrate to give pyrazole derivative 9. Refluxing of amino-1,3-thiazine derivative 1 with ethyl bromoacetate in the presence of Et3N produce the alkylated pyrimidine product 10. Hydrazonolysis of 1,3-thiazine 1 with hydrazine or phenyhydrazine gave pyrimidine derivatives 11a,b, respectively. Compound 11b was cyclized with carbon disulfide or formaldehyde to produce triazolopyrimidines 12 and 13, respectively. Some of the new compounds were screened for anticancer activity and significant results were found for some compounds.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 139-65-1 help many people in the next few years. COA of Formula: C12H12N2S.

Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem