Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner.10297-73-1, Name is 4′-(Methylsulfonyl)acetophenone, SMILES is C1=CC(=CC=C1[S](C)(=O)=O)C(C)=O, belongs to thiazines compound. However, they have proven to be challenging because of the mutual inactivation of both catalysts. In a document, author is Strzadala, Leon, introduce the new discover, SDS of cas: 10297-73-1.
An Anti-Inflammatory Azaphenothiazine Inhibits Interferon beta Expression and CXCL10 Production in KERTr Cells
An azaphenothiazine derivative, 6-chloroethylureidoethyldiquino[3,2-b; 2 0,3 0 -e][1,4]thiazine (DQT), has recently been shown to exhibit immunosuppressive activities in mouse models. It also inhibited the expression of CXCL10 at the protein level, at non-toxic concentrations, in the culture of KERTr cells treated with double-stranded RNA, poly(I:C). In this report, we demonstrated that DQT inhibits the transcription of the CXCL10 gene. Although CXCL10 is an IFN gamma-inducible protein, we found that the CXCL10 protein was induced without the detectable release of IFN gamma or I kappa B degradation. Hence, we concluded that IFN gamma or NF kappa B was not involved in the regulation of the CXCL10 gene in KERTr cells transfected with poly(I: C), nor in the inhibitory activity of DQT. On the other hand, we found that IFN beta was induced under the same conditions and that its expression was inhibited by DQT. Kinetic analysis showed that an increase in IFN beta concentrations occurred 4-8 h after poly(I: C) treatment, while the concentration of CXCL10 was undetectable at that time and started to increase later, when IFN beta reached high levels. Therefore, DQT may be regarded as a new promising inhibitor of IFN beta expression and IFN beta-dependent downstream genes and proteins, e.g., CXCL10 chemokine, which is implicated in the pathogenesis of autoimmune diseases.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 10297-73-1. SDS of cas: 10297-73-1.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem