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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW OXAZINES AND THIAZINES
In an approach to hostile the growing microbial drug resistance and to advance new antimicrobial moieties having more potent effect, here we have synthesized some novel substituted heterocyclic chalcone derivatives containing oxazine and thiazine moieties. Conversion of 2, 4-dihydroxyphenyl-3-phenylpropenones into 4-(2-hydrazinyl-6-phenyl-6H-1, 3-oxazin-4-yl) benzene-1,3-diols 3(a-i) was achieved by stirring 2(a-i) with semicarbazide in ethanolic sodium hydroxide. Similarly, conversion of 2(a-i) into 4-(2-hydrazinyl-6-phenyl-6H-1, 3-thiazin-4-yl) benzene-1, 3-diols 4(a-i) was achieved by stirring 2(a-i) with thiosemicarbazide in ethanolic sodium hydroxide. All the compounds were screened for in vitro antimicrobial, anti-inflammatory, and cytotoxic activity. The newly synthesized compounds exhibited significant inhibition values compared to standard drugs.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 92-39-7 help many people in the next few years. SDS of cas: 92-39-7.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem