Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Salem, Marwa S., once mentioned the application of 7143-01-3, Name is Methanesulfonic anhydride, molecular formula is C2H6O5S2, molecular weight is 174.196, MDL number is MFCD00007556, category is thiazines. Now introduce a scientific discovery about this category, Product Details of 7143-01-3.
Design, Synthesis and Antiproliferative Activity of Novel Heterocycles from 6-Iodo-2-phenyl-4H-benzo[d][1,3]thiazine-4-thione
The present work is dedicated to utilize the reactivity of 6-iodo-2-phenyl-4H-benzo[d][1,3]thiazine-4-thione to motivate new different heterocyclic systems namely, quinazoline-4(3H)-thione,benzimidazol-2(3H)-one, pyrazole and thiadiazole derivatives which have been structurally characterized with spectroscopic data such as IR, (HNMR)-H-1 and mass spectra. The synthesized compounds were evaluated for the anticancer activity against HePG-2 and MCF-7 cell lines. 1-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-(6-iodo-2-phenyl-4-thioxoquinazolin-3(4H)-yl)ethanone and ethyl 3-(2-(2-(6-iodo-2-phenyl-4-thioxoquinazolin-3(4H)-yl)acetyl)hydrazono)butanoate showed the highest cytotoxic activities against the two cell lines comparable to that of the reference compound doxorubicin. Most of the synthesized compounds also exhibited good cytotoxic activity.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem