82911-69-1, Name is N-(9-Fluorenylmethoxycarbonyloxy)succinimide, molecular formula is C19H15NO5, Quality Control of N-(9-Fluorenylmethoxycarbonyloxy)succinimide, belongs to thiazines compound, is a common compound. In a patnet, author is Tadano, Genta, once mentioned the new application about 82911-69-1.
Discovery of an Extremely Potent Thiazine-Based beta-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose
Genetic evidence points to deposition of amyloid-beta (A beta) as a causal factor for Alzheimer’s disease. A beta generation is initiated when beta-secretase (BACE1) cleaves the amyloid precursor protein. Starting with an oxazine lead 1, we describe the discovery of a thiazine-based BACE1 inhibitor 5 with robust A beta reduction in vivo at low concentrations, leading to a low projected human dose of 14 mg/day where 5 achieved sustained A beta reduction of 80% at trough level.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 82911-69-1 help many people in the next few years. Quality Control of N-(9-Fluorenylmethoxycarbonyloxy)succinimide.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem