The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 7143-01-3, 7143-01-3, Name is Methanesulfonic anhydride, SMILES is CS(=O)(OS(C)(=O)=O)=O, in an article , author is Mahmoud, N. A., once mentioned of 7143-01-3.
Synthesis of Polynuclear Heterocyclic Compounds Derived from 1-Biphenyl-4-yl-4-(1-methyl-1H-benzimidazol-2-yl)-But-2-en-1-One with Expected Biological Activity
NUCLEOPHILIC addition of barbituric acid, thioglycolic acid with malononitrile and 3-Amino-5-pyrazolinone with 1-Biphenyl-4-yl-4-(1-methyl-1H-benzimidazol-2-yl)-but-2-en-1-one (1) gives pyrimidine, Thiazol and pyrazolinone derivatives (2-4), repectively. Compound 4 which reacted with Arylidene malononitrile in ethanol to give pyrano derivatives (5). Cyclocondensation of chalcone (1) with thiourea under reflux in ethanolic NaOH led to thiazine derivative (6) and treatment of (6) with bromine-acetic acid mixture afforded compound (7) similarly, cyclization of chalcone (1) with orthophenylinediamine in Dimethylformamide (DMF) gave diazepine derivatives (8). Also, chalcone (1) reacted with 3-Amino-5-pyrazolinone in ethanol to give pyrazolinone derivative (9). (Scheme 1). The condensation of compound (1) with 2-cyanoacetohydrazide through the acid-catalyzed reaction to form the Schiff base (10) by heating in 96% acetic acid gave the diazetidine derivative (11) which upon reaction with phosphorous oxychloride gave the chlorodiazetidine derivative (12), the latter compound reacted with 2ry amines and yielded the substitueted amino diazetidine derivatives (13(a-c)). On the other hand, the Schiff bases (14) produced from condensed compound (1) with 2-Amino-2-(hydroxy methyl) propane-1,3-diol in ethyl alcohol which reacted with phosphorous oxychloride gave the propanol derivatives (15). Finally, the cyclization reaction of compound (1) with 2-aminophenol and 2-aminothiophenol in dry benzene formed compounds (16, 17), repectively.(Scheme 2).
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem