In an article, author is Bairam, Ravindar, once mentioned the application of 66-27-3, COA of Formula: C2H6O3S, Name is Methyl methanesulfonate, molecular formula is C2H6O3S, molecular weight is 110.13, MDL number is MFCD00007557, category is thiazines. Now introduce a scientific discovery about this category.
ANTICONVULSANT EVALUATION OF SOME NOVEL 1, 3-THIAZINE DERIVATIVES
In the present study, a series of novel biologically active 8-benzylidene-6-tert-butyl-4-phenyl-5, 6, 7, 8-tetrahydro-benzo-1, 3-thiazin – 2 -imines (TB1-TB12) were synthesized and evaluated for their biological activities. Initially, 2,6-dibenzylidene-4-tert-butylcyclohexanones were synthesized by Claisen-Schmidt condensation of 4-tert-butylcyclohexanone with various aromatic aldehydes in the presence of dilute sodium hydroxide. Further these compounds were subjected to cyclocondensation with thiourea, in isopropyl alcohol, catalyzed by aqueous potassium hydroxide to form 4-aryl-8-arylidene-5,6,7,8-tetrahydro-1H-benzo[d][1,3] thiazin-2(4H)-imines (TB1-TB12). The structures of the newly synthesized compounds have been established on the basis of their spectral data and elemental analysis. Anticonvulsant activity was performed by Maximal electroshocks (MES) method by using Diazepam as standard reference. These compounds were subjected to molecular properties prediction, drug-likeness, lipophilicity and solubility parameters determination using Molinspiration, Osiris program was used for prediction of the toxicity, and also Molsoft and ALOGPS 2.1 softwares. Among all compounds TB5 and TB8 containing lipophilic methoxyl and isopropyl group were more potent whereas TB12 containing hydroxyl groups were least potent among the series.
If you are interested in 66-27-3, you can contact me at any time and look forward to more communication. COA of Formula: C2H6O3S.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem