In an article, author is Garcia-Losada, Pablo, once mentioned the application of 139-65-1, Name is 4,4-Thiodianiline, molecular formula is C12H12N2S, molecular weight is 216.3, MDL number is MFCD00025342, category is thiazines. Now introduce a scientific discovery about this category, Computed Properties of C12H12N2S.
Synthesis, Optimization, and Large-Scale Preparation of the Low Dose Central Nervous System-Penetrant BACE1 Inhibitor LY3202626 via a [3+2] Nitrone Cycloaddition
Herein we report a summary of the synthetic development of LY3202626 from the initial discovery route to a final route that was scaled to make 150 kg. Key developments include the use of a [3 + 2] cyclization to set the cis ring junction of the formed isoxazoline, a one-pot thiazine formation, and three different ways to install the aniline: (1) Cu-catalyzed azide coupling and reduction, (2) nitration and reduction, and (3) Buchwald coupling with acetamide.
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Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem