Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.92-30-8, Name is 2-(Trifluoromethyl)-10H-phenothiazine, SMILES is FC(C(C=C1N2)=CC=C1SC3=C2C=CC=C3)(F)F, belongs to thiazines compound. In a document, author is Pluta, Krystian, introduce the new discover, Safety of 2-(Trifluoromethyl)-10H-phenothiazine.
The Smiles rearrangement in the syntheses of azaphenothiazines. Part II. The review of the various types of phenyl azinyl and diazinyl sulfides undergoing this rearrangement
Azaphenothiazines are one of the most bioactive heterocyclic scaffolds in medicinal chemistry. This review discusses the Smiles rearrangement of over 40 types of phenyl azinyl sulfides and diazinyl sulfides during syntheses of azaphenothiazines. These syntheses consist of two (rearrangement/cyclization) or three steps (sulfide formation/rearrangement/cyclization) proceeding often rapidly without isolation of intermediates. The rearrangement depends on the nature of sulfides, steric hindrance, reaction conditions (basic, but also weakly and strongly acidic, and even neutral and thermal). Some reaction conditions and catalysts favor direct cyclization. This review arranges the knowledge of the Smiles rearrangement of phenyl azinyl and diazinyl sulfides but also systematizes the syntheses of monoaza-, diaza-, triaza-, tetraazaphenothiazines and their benzo- and dibenzo derivatives. The review shows that some formed azaphenothiazines were wrongly identified and not all wrong structures have been corrected. Some syntheses cannot be defined as proceeding with the rearrangement or not when both the rearranged and direct products are the same. The structure analysis of resulted azaphenothiazines is crucial (the most reliable: X-ray analysis or two-dimensional NMR). The authors hope that this review will prompt researchers to revisit some syntheses of azaphenothiazines. (C) 2020 Elsevier B.V. All rights reserved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 92-30-8 is helpful to your research. Safety of 2-(Trifluoromethyl)-10H-phenothiazine.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem