Reference of 66-27-3, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 66-27-3, Name is Methyl methanesulfonate, SMILES is CS(=O)(OC)=O, belongs to thiazines compound. In a article, author is Ghandi, Mehdi, introduce new discover of the category.
Synthesis, characterization and in vivo evaluation of [Zn-62]-benzo-delta-sultam complex as a possible pet imaging agent
Objective The development of a new tracer based on the cyclic sulfonamides (sultams) was investigated. Methods 3-(Methoxy-phenyl-methyl)-1,6-dimethyl-1H benzo[c][1,2] thiazine 2,2-dioxide (benzo-delta-sultam) was synthesized and characterized by elemental analysis, FT-IR spectroscopy and single crystal X-ray structure determination. The prepared cyclic sulfonamide was labeled with non-commercial Zn-62 radioisotope for fast in vivo targeting and Coincidence imaging purposes (radiochemical purity 97 % ITLC, 96 % HPLC, specific activity 20-23 GBq/mmol). In vivo biodistribution of the final complex was investigated in Sprague Dawley (R) rats bearing fibro sarcoma tumor after 2, 4 and 8 h post injection and compared with free Zn+2 cation. Results Using instant paper chromatography method, the physicochemical properties of labeled compounds were found sufficiently stable in organic phases, e. g. a human serum, to be reliably used in bioapplications. Conclusions The complex exhibited a rapid as well as high tumor uptake (tumor to blood ratio 4.38 and tumor to muscle ratio 9.63) resulting in an efficient tumor targeting agent.
Reference of 66-27-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 66-27-3.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem