Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 92-39-7, Name is 2-Chloro-10H-phenothiazine, SMILES is ClC(C=C1N2)=CC=C1SC3=C2C=CC=C3, in an article , author is Winneroski, Leonard L., once mentioned of 92-39-7, COA of Formula: C12H8ClNS.
Preparation and biological evaluation of conformationally constrained BACE1 inhibitors
The BACE1 enzyme is a key target for Alzheimer’s disease. During our BACE1 research efforts, fragment screening revealed that bicyclic thiazine 3 had low millimolar activity against BACE1. Analysis of the co-crystal structure of 3 suggested that potency could be increased through extension toward the S3 pocket and through conformational constraint of the thiazine core. Pursuit of S3-binding groups produced low micromolar inhibitor 6, which informed the S3-design for constrained analogs 7 and 8, themselves prepared via independent, multi-step synthetic routes. Biological characterization of BACE inhibitors 6-8 is described. (C) 2015 Elsevier Ltd. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 92-39-7, you can contact me at any time and look forward to more communication. COA of Formula: C12H8ClNS.
Reference:
Thiazine – an overview | ScienceDirect Topics,
,Thiazine | C4H5NS – PubChem