Awesome and Easy Science Experiments about Synthetic Route of 1910-85-6

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about Synthetic Route of 1910-85-6

Synthetic Route of 1910-85-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.Synthetic Route of 1910-85-6, Name is 1-Chloro-10H-phenothiazine, molecular formula is C12H8ClNS. In a Article, authors is Self, Jennifer L.£¬once mentioned of Synthetic Route of 1910-85-6

REACTION OF CHLORO DERIVATIVES OF 10-BENZYL- AND 10-(4′-FLUOROBENZYL)PHENOTHIAZINES WITH NITRILES AND AMINES UNDER ARYNE-FORMING CONDITIONS

2-Chloro-10-benzylphenothiazine (1) and 2-chloro-10-(4′-fluorobenzyl)phenothiazine (2) react with aliphatic nitriles (3 and 4) and LDA to yield typical 2-substituted aryne products (9a,b and 9g,h, respectively).However, treatment of 1 with aromatic nitriles (5-8) and LDA supplies 2-(arylmethyl)-1-cyano rearranged nitriles (10c-f), whereas 2, when treated similarly, affords both rearranged nitriles (10i-l) and typical 2-arylated nitrile products (9i-j).An explanation in terms of the effect of substituents on the competing aryne and tandem addition-rearrangement pathways is presented.The crystal structure of one of the rearranged 1-cyanophenothiazines (10c) was obtained and reveals that the molecule adopts the “extra” conformation in which the 10-benzyl group is in the pseudo axial position.The reaction of 1 and 2 with various lithium amides in the corresponding free amine solvents gives the corresponding 2-aminated products (11) and (12) in excellent yields.Both 1-chloro-10-benzylphenothiazine (18) and 1 supply the same product, 10-benzyl-2-N,N-diisopropylaminophenothiazine (11a), when made to react with LDA in diisopropylamine solvent, indicating that each of these reactions proceeds via the same aryne intermediate, and not through the SRN1 mechanism.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about Synthetic Route of 1910-85-6

Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem