3080-99-7, Name is 3,4-Dihydro-2H-benzo[b][1,4]thiazine, belongs to thiazines compound, is a common compound. 3080-99-7In an article, authors is Babudri, F., once mentioned the new application about 3080-99-7.
Eliminative Ring Fission of 4-Acyl-2,3-dihydro-4H-1,4-benzothiazines
The behavior of 4-acyl-2,3-dihydro-1,4-benzothiazines 1-11 upon treatment with lithium diisopropylamide (LDA) in THF at -78 deg C has been examined.Very marked differences have been observed.Whereas unsubstituted and monosubstituted derivatives (1-4) readily undergo “eliminative ring fission”, providing 2-(alkylthio)phenylenamides 12, 2-aminophenyl vinyl sulfides 16, and 3-acylbenzothiazolines 13, 2,3-disubstituted derivatives (5-7) do not react at all.The relationship between structural features of the above-mentioned dihydrobenzothiazines and their reactivity is considered.Lithium ion plays a fundamental role in providing activation for the ring-opening reaction.
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Reference£º
Thiazine – an overview | ScienceDirect Topics,
Thiazine | C4H5NS – PubChem