272437-84-0, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.272437-84-0, name is :3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid. An updated downstream synthesis route of 272437-84-0 as follows.
Preparation of 3-oxo-3,4-dihvdro-2H-benzori,41thiazine-6-carboxylic acid (l-[2-(7- methoxy-quinoxalin-2-ylsulfanyl)-ethvH-piperidin-4-vU -methyl-amide: 3-oxo-3,4-dihydro-2H-benzo[l,4]thiazine-6-carboxylic acid (26 mg, 0.11 mmol, 1.0 eq) is added at room temperature to a stirred solution of {l-[2-(7-methoxy-quinoxalin-2- ylsulfanyl)-ethyl]-piperidin-4-yl}-methyl-amine (40 mg, 0.11 mmol, 1.0 eq) in N,N- dimethylformamide (3 mL), followed by O-(7-azabenzotriazol-l-yl)-iV,iV,N’,N’- tetramethyluronium hexafluorophosphate (45 mg, 0.11 mmol, 1.0 eq), and triethylamine (16 muL, 0.11 mmol, 1.0 eq). After 4 hours stirring at room temperature, solvent is evaporated and the residue is purified by preparative EtaPLC to afford 3-oxo-3,4-dihydro-2H- benzo[l,4]thiazine-6-carboxylic acid {l-[2-(7-methoxy-quinoxalin-2-ylsulfanyl)-ethyl]- piperidin-4-yl} -methyl-amide as a yellow solid (22 mg, 35% yield).MS m/z (+ESI): 524.3 [M+Eta]”
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Reference£º
Patent; BASILEA PHARMACEUTICA AG; GAUCHER, Berangere; DANEL, Franck Hubert; ROUSSEL, Patrick; WO2010/84152; (2010); A1;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem