As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 92-30-8,2-(Trifluoromethyl)-10H-phenothiazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.92-30-8
92-30-8, A solution of2- (trifluoromethyl)-lOH-phenothiazine (2.04g, 7.6mmol) and DMF (16mL) was mixed with CS2C03 (7.5g, 22.9mmol) and l-bromo-3-chloropropane (1.1 mL, 11.5mmol). The reaction mixture was heated at 65 C for 12h. Once no starting material was observed by analytical LCMS, EtOAC (250mL) and brine (250mL) were added. The organic layer was separated, and the aqueous layer was washed with EtOAC (3 chi l00mL). The combined organic extracts were washed with brine (2 chi lOOmL), dried over MgSO iota, and concentrated to afford the title compound.
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Reference£º
Patent; INCEPTION 1, INC.; CHEN, Austin, Chih-Yu; SCOTT, Jill, Melissa; STEARNS, Brian, Andrew; STOCK, Nicholas, Simon; TRUONG, Yen, Pham; WO2013/43744; (2013); A2;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem