The origin of a common compound about 2-(Trifluoromethyl)-10H-phenothiazine

This compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92-30-8,2-(Trifluoromethyl)-10H-phenothiazine,its application will become more common.

A common heterocyclic compound, 92-30-8,2-(Trifluoromethyl)-10H-phenothiazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 92-30-8

General procedure: Phenothiazine 1 (5g, 25.09mmol) was taken in anhydrous N, N-dimethyl formamide (DMF) (50mL) in a dry round bottom flask. Sodium hydride (2g, 50.18mmol) was added under nitrogen condition at 0C and stirred for 30min at room temperature. Methyl iodide (3.4mL, 50.18mmol) was added and continued the stirring for 8h. After that, the reaction mixture (monitored by TLC) was quenched with ice cold water (150mL). The separated solid was filtered off, dried and used as such for the next step.

This compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92-30-8,2-(Trifluoromethyl)-10H-phenothiazine,its application will become more common.

Reference£º
Article; Reddyrajula, Rajkumar; Dalimba, Udayakumar; Madan Kumar; European Journal of Medicinal Chemistry; vol. 168; (2019); p. 263 – 282;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem