As a common heterocyclic compound, it belong thiazines compound,2-(Trifluoromethyl)-10H-phenothiazine,92-30-8,Molecular formula: C13H8F3NS,mainly used in chemical industry, its synthesis route is as follows.,92-30-8
General procedure: To a stirred solution of phenothiazine or 2-(trifluoromethyl)-10H-phenothiazine (3 mmol) in dichloromethane (20 mL), K2CO3 (5 mmol) and propargyl bromide (5 mmol) were added carefully and the reaction mixture was refluxed for 7 h. After the reaction, the system was concentrated under vacuum, the residue was dissolved in EtOAc (40 mL) and washed by pure water and brine, and dried over anhydrous Na2SO4 and concentrated under vacuum to afford crude products 8a-8b, which were used in the next reaction without further purification.
With the synthetic route has been constantly updated, we look forward to future research findings about 2-(Trifluoromethyl)-10H-phenothiazine,belong thiazines compound
Reference£º
Article; Zhang, Jun-Xia; Guo, Jiao-Mei; Zhang, Ting-Ting; Lin, Hong-Jun; Qi, Nai-Song; Li, Zhen-Guo; Zhou, Ji-Chun; Zhang, Zhen-Zhong; Molecules; vol. 23; 6; (2018);,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem