1771-18-2 A common heterocyclic compound, 1771-18-2,2-Methoxyphenothiazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step a 4-(3′-indolyl)-1-[1″-(2′”-methoxy-10′”-phenothiazinyl) -2″-methyl-3″-propionyl]-piperidine hydrochloride A mixture of 23 g of 2methoxy-phenothiazine, 21 g of methacryloyl chloride and 120 ml of toluene was refluxed for 3 hours and was then cooled and washed with 250 ml of N sodium hydroxide. The organic phase was decanted and the aqueous phase was washed twice with 50 ml of toluene. The combined organic phases were washed with water, dried over magnesium sulfate, treated with carbon black and evaporated to dryness to obtain 29.6 g of 2-methoxy-10-(alpha-methyl acryloyl)-phenothiazine melting at 91-92 C., 1771-18-2
This compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1771-18-2,2-Methoxyphenothiazine,its application will become more common.
Reference£º
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Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem