With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92-30-8,2-(Trifluoromethyl)-10H-phenothiazine,as a common compound, the synthetic route is as follows.
Step a 4-(3′-indolyl)-1-[1″-(2′”-trifluoromethyl-10′”-phenothiazinyl)-2″-methyl-3″-propionyl]-piperidine hydrochloride 27 g of 2-trifluoromethyl-phenothiazine and 12 g of alpha-methylacryloyl chloride in 100 ml of toluene were 1 for 2 hours and the mixture was evaporated to dryness. The residue was chromatographed over silica gel and elution with a 1– 1 benzene-cyclohexane mixture gave 18 g of 2-trifluoromethyl-10-(alpha-methyl acryloyl)-phenothiazine in the form of white crystals melting at 103¡ãC.
The synthetic route of 92-30-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Roussel-UCLAF; US3988453; (1976); A;,
Thiazine – an overview | ScienceDirect Topics
Thiazine | C4H5NS – PubChem